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(PubMed) Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ

Stable improvement in function and reduced pain indicate whether additional intervention is necessary

Additionally, copper participates in the autophagy process, as it is essential for the activity of autophagy kinases, including MEK1/2 and ULK1/2 [150]

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Based on these biochemical considerations and clinical studies, when appropriate, we recommend providing natural or chemical antioxidants as a complement to the ordinary pharmacological treatment of diseases that involve OS