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Best Pract Res Clin Rheumatol 36(3):101773 Bang JS, Choi HM, Sur BJ, Lim SJ, Kim JY, Yang HI, Yoo MC, Hahm DH, Kim KS (2009) Anti-inflammatory and anti-arthritic effects of piperine in human interleukin 1-stimulated fibroblast-like synoviocytes and in rat arthritis models

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There are in vitro observations that copper ions can inhibit the enzyme under specific laboratory conditions, but extrapolating this to a clinically meaningful, finasteride-like local DHT blockade on a human scalp is not supported by controlled human data

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As an amphiphilic, pleiotropic indoleamine, melatonin has both direct actions and receptor-mediated effects