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In the confirmatory cohort (observational study), all patients (4 men and 9 women) were submitted to mRYGB surgery

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The endometriums dynamic nature arises from its responses to the oscillating ovarian hormones estradiol (E2), a form of estrogen, and progesterone (P4)which are regulated by the hypothalamic-pituitary axis

some experience symptom improvement after several weeks, whereas others suffer long-term cognitive problems that severely impact daily life and work performance (44, 45) ( Figure 1 )

Evidence for gut microbiota involvement in anxiety disorders is consistent across human studies and strongly supported by preclinical mechanistic data, with therapeutic interventions showing early promise in randomized controlled trials, yet still requiring a large-scale validation

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