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23 Biophysical modalities like Blood Flow Restriction (BFR), continuous passive motion, strength training, and intermittent negative pressure influence tissue healing at the molecular level by altering cellular ion channels, membrane potentials, and intracellular signaling
We also showed that inhibition of EPAC increased mitochondrial ROS production only in primary melanoma cells consistent with the role of EPAC-RAP1 signaling in maintaining mitochondrial integrity by suppressing mitochondrial ROS production and oxidative damage [5, 9]
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