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In rats, it may be activated by peripheral signals, such as distension of the stomach that activate the GLP-1expressing neurons of the NTS, 28 and it has also been associated with enteroceptive stress

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Because tirzepatide influences multiple metabolic pathwaysincluding glucose homeostasis, lipid metabolism, and inflammatory markersit has the potential to affect various laboratory parameters that clinicians routinely monitor in patients with obesity and metabolic disease

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American College of Lifestyle Medicine et al