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Therefore, PYY (3-36) not only reduces body weight by decreasing food intake through the CNS but also contributes to weight loss by regulating the gut microbiota and increasing the secretion of beneficial intestinal hormones

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[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Daniels S., Karlsson C., Schrauwen P., Parker V.E.R

Every time you increase the dose, the side effect cycle restarts

These results were widely covered in medical media and prompted Eli Lilly to advance retatrutide into a large-scale Phase 3 program