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The investigational drugs that are in various phases of development include exendin-(9-30) (Eiger Biopharmaceutical, Paol Alto, CA, USA), a potent GLP-1R antagonist (87,106), glucagon-based drugs (107,108), somatostatin analogues (109) and sodium-glucose cotransporter-1 inhibitor (110)

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All authors contributed to interpretation of data and contributed to the discussion and critically reviewed and edited the manuscript

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[15] [16] The effects on tolerability with extended dosing intervals have not been systematically studied