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Ophthalmic acid elevates liver ophthalmic acid levels 20-fold while depleting hepatic glutathione in Cystathionine -synthase -deficient mice with genetic homocystinuria [1]

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Once the tumour became arrested in the palbociclib-treated group, mice were further randomized to receive either RSL3 (50 mg kg 1 , five times per week for 2 weeks) or the vehicle, resulting in four experimental groups: vehicle, RSL3, palbociclib and palbociclib + RSL3