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Using Mendelian randomization, it was found that PMOS has causal links to sex hormone-binding globulin level, anti-Mllerian hormone (AMH) level, menopause age, body fat percentage, insulin resistance, depression, breast cancer, ovarian cancer, obsessive-compulsive disorder, and lung capacity

Inject into the abdomen, thigh, or upper arm

In clinical trials, retatrutide has shown larger average weight reductions (~30%) than tirzepatide (~21%) or semaglutide (~15%), which researchers attribute to its additional glucagon receptor activity

Therefore, clinicians should focus on individualized risk assessment, transparent counseling, and shared decision-making to guide appropriate therapy

As part of the GLP-1 agonist family, it mimics the glucagon-like peptide-1 hormone, which plays a crucial role in regulating blood sugar