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Airway smooth muscle (ASM) plays a central role in asthma pathophysiology

Further, the PI3K/Akt/GSK-3 signaling pathway regulates mitochondrial complex I activity, which is essential for mitochondrial function, energy metabolism, and redox balance (Li et al., 2013)

doi: 10.3389/fmicb.2018.01166 75 YuZ.ChenJ.LiuY.MengQ.LiuH.YaoQ.et al

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157 FMRP is an RNA-binding protein whose target mRNAs encode transcription factors, and chromatin modifiers have been identified by high-throughput sequencing of RNA isolated with cross-linking immunoprecipitation (HITS-CLIP)