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The primary outcome measures are changes in CSF A40 and A42 levels, vascular dysfunction biomarker levels, and scores of the MontgomeryAsberg Depression Ratio Scale at week 8

Oral semaglutide is a GLP-1 receptor agonist that must be taken on an empty stomach with specific timing around food and drinks

DPP-4 involvement in immune regulation, cardiovascular function, and inflammation: 2.3.1

Known as the body's master antioxidant, glutathione plays a crucial role in detoxification, immune function, and skin health

Acknowledgements The authors thank members of the Higley laboratory, J

MC5R: While it appears to be expressed across multiple tissues, the precise physiological function of MC5R remains somewhat elusive, though it is speculated to play a role in exocrine processes