The pharmacokinetic rationale is questionable given tirzepatide 5-day half-life
However, systemic inflammation can reduce plasma PLP levels even when a true deficiency is absent
Sikiri, Melanoma Research, 2004, 14 (4), A14A15)
Absolute values of body weight development (ce) and total change in body weight (f) of 33-wk old male C57BL/6 J wildtype (WT) or Vgat-Gipr knockout (KO) mice treated daily over 24 days with either vehicle, acyl-GLP-1 (10 nmol/kg), or the combination of acyl-GLP-1 (10 nmol/kg) and a GIPR antagonist (1,500 nmol/kg) (n = 8 each group)
Weight loss and metabolic improvements can occur from both oral and injectable GLP-1 medication
The only thing to note here is that not everywhere are the valuations attractive enough because in some cases the market has recognized the coming growth cycle and has started to price that in