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Phosphate overload in CKD not only exacerbates eryptosis and shortens RBC lifespan but also contributes to vascular calcification and other cardiovascular complications, making phosphate control a critical component of CKD management (Barreto et al., 2019)
Glomerular endothelial injury was dominant, resulting in an increase in thrombotic microangiopathy, collapsing glomeruli, and a decreased number of endothelial cells in experimental RN
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