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Semaglutide and topiramate are two medications often used to help with weight loss

PMID 34015185

This powerful combination often leads to even more significant weight loss than GLP-1 medications alone

Results The gut microbiota affects locomotion via GLP-1 signaling Animals displayed altered locomotion when their gut microbiome was depleted 13,14,15,16 , suggesting that locomotion is associated with the status of bacterial colonization, specific bacteria, and their metabolites 13,14,15,16

But this is actively counterproductive