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This irritancy test approach may be extended to other similar compounds or minerals and can potentially predict the in vivo skin irritation response before conducting clinical testing on human subjects

This route of administration can be particularly beneficial for patients who have difficulty swallowing oral medications or for those where oral administration is not optimal due to gastrointestinal issues

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Methods 352 , 7180 (2010)

The researchers observed advanced cavernosal smooth muscle relaxation and increased amounts of nitric oxide synthase