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Melanocytes use an enzyme called tyrosinase to convert the amino acid tyrosine into eumelanin, which is a dark brown pigment

These superoxide radicals (O 2 ) come from NADPH oxidase (NOX) and the mitochondrial electron transport chain (ETC).Mechanistically, nonenzymatic lipid peroxidation starts when OH derived from the Fenton reaction extracts hydrogen atoms from the double-bonded carbon atoms of PUFAs, forming phospholipid radicals (PL ) with a carbon-centered structure

PMCID: PMC12943208

doi: 10.3390/nu13030986