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[126] showed that patients with IPF had a fourfold lower concentration of GSH when compared to healthy individuals, suggesting that GSH deficiency in these patients contributes to the oxidativeantioxidant imbalance of the lower respiratory tract, causing greater damage to the cells of the lung parenchyma

RIP3 translocation into mitochondria promotes mitofilin degradation to increase inflammation and kidney injury after renal ischemia-reperfusion

The medication carries a boxed warning regarding thyroid tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

The highest monotherapy dose studied is 4.5 mg per week (Lancet 2021 Phase 2)

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