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Even though this effect may be mediated by the insulin receptor, experimental KO mice for the insulin receptor gene show a potent glucose lowering effect of IGF-1, indicative that the hypoglycaemic effect is also mediated, in part, by its own IGF-1R

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doi:10.1016/j.cmet.2018.03.001 Holst JJ, Rosenkilde MM

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Cutan Med