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They observed that COMBI therapy was superior to LIRA and MET monotherapy in reducing weight, BMI, and WC in women with PCOS previously poor responders to weight loss on metformin monotherapy

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Volumetric analyses demonstrate reductions in hippocampal and cortical gray matter, consistent with impaired synaptic plasticity (77, 78)

Rarely, mild allergic reactions, temporary redness at the injection site, or light gastrointestinal upset may occur

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