Zhengzhi et al
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Lipid nanoparticle technology for clinical translation of siRNA therapeutics
Our in vivo animal model demonstrated that physiologically relevant circulating phenolic metabolites mixtures, when administered intravenously, led to an increase in FMD (Reference Rodriguez-Mateos, Istas and Boschek38)
However, the t 1/2 in the plasma was less than 6 h, which failed to meet the stability requirement of ADCs