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The primary concerns include potential additive effects on blood glucose levels (particularly important for people with diabetes) and exacerbation of gastrointestinal side effects such as nausea and diarrhoea

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An oral NAC supplementation trial is underway to assess changes in brain GSH levels using similar 1 H-MRS

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Prone positioning In the supine position, the V/Q mismatch leads to poor oxygenation