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I hope you will find this brief review of the peptide landscape helpful

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Epub 2021 Feb 22

Shi Z, et al

46 showed interesting activity for XO (IC 50 = 0.043 M) with two substituents on the benzene ring, 3chloro and 4methyl, however, when one of the substituents was removed, generating 47 and 48 , with the 4methyl and 3chloro groups, respectively, the XO inhibitory activity improved more than tenfold for 47 and in the case of 48 it improved more than sevenfold, being more potent than febuxostat itself, which showed an IC 50 value of 0.008 M (Figure 15)