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It's aggregated anecdote, not evidence

Instead, it is broken apart during digestion

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More serous B12 deficiencies have the potential to impair heart and neurological function, leading to a wide range of serous symptoms, including but not limited to tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia, and changes in reflexes

Curcumin metabolites The figure shows pathways of curcumin metabolism with chemical structures

Qiu, X., Dong, K., Guan, J