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10.3233/JAD-230911 139 TianX.GaoY.KongM.ZhaoL.XingE.SunQ.et al (2023)

GSDMD has the ability to bind lipid and form protein pores on cell membranes, leading to plasma membrane rupture, cell swelling, release of intracellular substances including IL-1 and IL-18, and eventually cell death [6]

Inflammatory conditions like ulcerative colitis and Crohns disease trigger debilitating symptoms

These results suggest that TP activity is required for the enhanced expression of IL-8 mRNA and thymidine-derived metabolites are involved in the enhanced expression of IL-8 in those cells

What Comprises the Redox Communication System

Shen, X.-M., Xia, B., Wrona, M