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The translational meaning for an exogenous TB-500 fragment in humans is unknown, but it is the most-cited theoretical risk in clinician reviews of this stack and is one reason researchers exclude individuals with active or undiagnosed cancer from any informal protocol

Any off-label, personal, or clinical use is strictly outside the intended scope of supply

High doses are generally considered safe, though some people may experience minor side effects

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These effects support both internal connective tissue health and visible refinement of skin structure and tone