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In terms of the ameliorative effects of NAC against such complications, the initial evidence from Nakano and colleagues [53,54] showed that NAC at 150 mg/kg body weight was able to significantly improve GSH levels to ameliorate steatotic livers before cold storage

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Both activate AMPK, but through distinct mechanisms: metformin inhibits complex I of the mitochondrial electron transport chain, raising the cellular AMP:ATP ratio and thereby activating AMPK indirectly

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