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The overexpression of these genes is considered a major cause of tumor relapse and treatment failure

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the induction process results in a large increase in the enzyme activity of multiple CYPs including the CYP1A subfamily 23

In an experimental model, transgenic mice expressing a kinase-deficient IGF-1R -subunit (thus displaying reduced signal transduction in both IGF-1R and hybrid receptors) developed diabetes early on life [162, 236]

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Nevertheless, a 2017 systematic review on the impact of soluble fiber on weight loss found that some positive effects can be seen on the order of several weeks