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Statistical comparisons of measured indices among the three treatments were performed by Analysis of Variance followed by Student Neuman Keuls's multiple-comparison test

However, preclinical studies demonstrate therapeutic effects with once-daily or even less frequent administration, suggesting tissue distribution, receptor binding, or cellular signaling effects extend beyond plasma clearance

To test the effect of Sp in paraquat-induced oxidative stress model, seven days old wild type flies, constitutively expressing mitochondrial (mt)-roGFP, were exposed to 10 mM paraquat for 24 h and then co-treated with 2.5 mM Sp for 24 h, prior to roGFP fluorescence estimation

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Gleeson LM, Chakraborty C, McKinnon T, Lala PK