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Autophagy is a highly conserved and tightly controlled cellular process responsible for the degradation of the damaged cytoplasmic organelles, misfolded proteins, and other macromolecules within the lysosome (Miller et al., 2010

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Such an indication is unique from most other drugs and compounds identified by the NIA-supported Intervention Testing Program (ITP) to improve lifespan, as acarbose, 17--estradiol, nondihydroguaiaretic acid (NDGA), and protandim, all preferentially improve male lifespan 35,36

Before comparing them, one fact has to sit at the front: as of mid-2026, neither cagrilintide nor retatrutide is approved by the U.S

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