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Uracil- and pyridine-containing HDAC inhibitors displayed cytotoxicity in colorectal and glioblastoma cancer stem cells

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However, as a macromolecular polysaccharide, the bioavailability of APS is extremely low, the oral absorption efficiency and its specific form in vivo are still unclear, and the current mechanism is not deep enough, lack of loss-of-function validation, and its purity and homogeneity also pose a challenge to the assessment of pharmacological effects