Gastrointestinal Side Effects Both semaglutide and alcohol can cause digestive discomfort, and combining the two may worsen these effects: Delayed Stomach Emptying Semaglutide slows down digestion, meaning alcohol stays in your system longer and may have a stronger effect than expected
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Combined, they may produce symptomatic hypoglycemia, particularly in patients who are also taking a sulfonylurea or insulin alongside their GLP-1