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The Ozempic prescribing information lists three indications, all in type 2 diabetes: glycemic control, reduction of major adverse cardiovascular event risk in adults with established cardiovascular disease, and reduction of the risk of sustained eGFR decline, end-stage kidney disease and cardiovascular death in adults with chronic kidney disease
Boyi Gan and colleagues defined disulfidptosis in 2023 as high SLC7A11 expression and NADPH depletion, resulting in the suppression of cystine/cysteine conversion under conditions of glucose starvation, which leads to disulfide bond accumulation, disulfide stress, and collapse of the cytoskeleton
Someone should do better
For women 40+, expect 0.51 pound per week with more weekly fluctuation due to hormonal cycles, water retention, and cortisol sensitivity
It increases insulin and blood sugar levels, encouraging fat storage in the body
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