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This is all very hand-wavy theory right now, but could it be the insulin thats having some of these effects in the brain? It is clear that insulin dysregulation affects the brain, as evidenced by certain neurodegenerative diseases

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Signaling pathways are complex networks of molecules that transmit signals from the external environment of the liver to initiate internal mechanisms, effectively guiding repair and regeneration processes

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doi: 10.1007/s10620-016-4054-0 8 TilgHMoschenARRodenM