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The core mechanisms include reduced activity of GPX4 and depletion of GSH, along with decreased levels of antioxidant enzymes such as SOD and CAT, leading to severely impaired cellular ability to clear lipid peroxides (Jiang et al., 2021

[54], as an alternative to recombinant ApoE, two ApoE-derived peptides, dApoE-R9 and ApoE-F-R9, were synthesized as liver-targeting moieties of cationic liposomes

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Mechanism of Action in Research Models GIP receptor activation is studied in the context of incretin signaling, glucose-responsive pathways, and insulin physiology areas relevant to type 2 diabetes research models