Patients should be educated to recognize symptoms of thyroid dysfunction, track their weight and any changes in energy levels or other symptoms, and maintain a consistent schedule for both levothyroxine and GLP-1 medication administration
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When the medication is stopped, appetite and blood sugar regulation typically return to previous patterns, which can lead to weight regain
GLP-1 stimulates the -cells to produce Insulin, blocks pancreatic -cells' glucagon release via somatostatin (96), slows down gastric emptying (131), improves peripheral glucose tolerance (132), suppresses appetite in the hypothalamus and amygdala (97), increases -cell mass, GSIS, and elicits protection from glucolipotoxicity (133) and apoptosis (134)
