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Glutathione is not only vital to sperm antioxidant defenses, but selenium and glutathione are essential to the formation of phospholipid hydroperoxide glutathione peroxidase -an enzyme present in spermatids -which becomes a structural protein in the mid-piece of mature spermatozoa

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The most important intracellular sources include mitochondria, the endoplasmic reticulum, peroxisomes, NADPH, and other sources (Aranda-Rivera et al