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References Wilding JPH, et al

Dapagliflozin was negative in the Ames mutagenicity assay and was positive in a series of in vitro clastogenicity assays in the presence of S9 activation and at concentrations greater than or equal to 100 g/mL

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KK: Writing review and editing

(Phase 3 establishes efficacy and safety and is the last stop before a company would seek FDA approval for the drug.) Its hard to know for certain, but if all goes well, retatrutide may be available as early as 2027, says Rhodes

The exact half-life of retatrutide has not been published as a specific number in the major trial publications