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For many patients, the digestive discomfort gradually improves as the body adjusts to the medication, though the timeline varies considerably from person to person

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Retrieved 11 October 2015

Johnson, "A bird?s eye view of post-translational protein modifications and the regulation of spliceosome dynamics", Molecular Biosystems (2010)

These ligands include the endogenous substrate Tf and several different antibodies and peptides that bind to different epitopes of the receptor with Tf as the most extensively studied ligand for TfR-directed brain targeting [20]