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Clinical trials show semaglutide produces approximately 15% average weight loss compared to 5-8% with liraglutide

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In preclinical hepatocyte and rodent models, the compound is studied for its effects on lipogenesis, -oxidation enzymes, and de-novo lipogenic transcription factors such as SREBP-1c and ChREBP

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And a path to bariatric surgery if appropriate, he said, adding that the program delivers 19% sustained weight loss at 36 months