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Designing robust clinical trials to evaluate antioxidant therapies in HTN and DM requires addressing unique challenges, including patient heterogeneity, biomarker variability, and the dual role of OS as both cause and consequence of disease progression

Musculoskeletal injuries, gastrointestinal disorders, and vascular conditions represent logical initial targets given the preclinical database and potential clinical impact

Loren Pickart, then a graduate student at the University of California, San Francisco