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Evidence Limitations and Unanswered Questions The main evidence limitations for GHK-Cu are uneven human data, formulation differences, limited injectable safety information, small topical skin studies, indirect hair evidence, and uncertain long-term outcomes [2], [6], [7], [8]

Few GATM deficient patients have been identified, 40 GAMT deficient patients have been identified, and around 150 SLC6A8 deficient patients have been identified to date

Lower doses produce fewer side effects

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Note that strong chelators, phosphate-rich buffers and reducing agents in an experimental medium will compete for the copper centre and alter the species actually present

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