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Using streptozotocin-induced diabetic AD rats, other groups showed that metformin treatment improves learning and memory in streptozotocin-AD rats, associated with reduced astrogliosis, microgliosis, cytokine levels of IL1-, TNF-, and TGF- in hippocampal tissues of rats with AD (Pilipenko et al., 2020

A recent work has reported efficient degradation of histone deacetylase (HDAC) isoforms by means of USP14 interaction 43

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Targeting Senescent Cell Anti-Apoptotic Pathways (SCAPs) The development of senolytics to eliminate senescent cells (SnCs) is one of the strategies used to treat age-related diseases

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89 (10): 10011003 Heng M.C., Allen S.G