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[DOI] [PMC free article] [PubMed] [Google Scholar] 187.Fukamizu Y., Uchida Y., Shigekawa A., Sato T., Kosaka H., Sakurai T
The molecular mechanisms mediating the actions of metformin on hepatic glucose production remain incompletely understood and are thought to involve engagement of the AMP-activated protein kinase (AMPK) pathway and its upstream kinase, liver kinase B1 (LKB1) [3, 4]
It belongs to a novel class of agents known as triple receptor agonists, meaning it simultaneously activates three distinct hormone receptors: the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor
Sources include fatty fish, nuts (almonds, walnuts), olive oil, and avocados
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