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An open-label study (n=42) found that IV NAC (50 mg/kg) combined with oral NAC (500 mg twice daily) for 3 months increased brain glutathione levels (measured by MRS), increased dopamine transporter binding (measured by DaTscan), and improved UPDRS motor scores (Monti et al., PLoS One, 2016) [53]
Effects of DSIP in man: multifunctional psychophysiological properties
Interestingly, an antagonist of MC-4R had an opposite effect, suggesting that MC-4R activation by MT-2 influences preference for alcohol
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