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GSTM1 and GSTT1 are therefore the final enzymatic line of defense in the 4-OHE2 detoxification pathway the layer that becomes most consequential exactly when upstream clearance by COMT and SULT1A1 is most impaired

Understanding why GLP-1s affect digestion, what symptoms are common, and what can help may make it easier to manage side effects and decide what support you need