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Original characterization

104 A critical factor in this process is the quiescent state (G0 phase), allowing CSCs to evade chemotherapy and radiotherapy, which primarily target proliferating cells

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However, in MASH with significant fibrosis ( F2), pharmacological therapy provides measurable clinical benefits and should be considered with priority, especially if obesity or T2DM coexist (Fig

More than 80 affected targets have been identified, including those resulting from NO-system blockade as well as those from NO-system overactivity (for a review, see [11,29])

Tschen, S