4 The multiscale anticancer mechanisms of SFN: beyond Nrf2 and HDAC inhibition While the activation of Nrf2-mediated antioxidant response and inhibition of HDACs represent well-established mechanisms underlying SFNs anticancer properties, emerging evidence reveals a far more complex pharmacological profile
Twelve weeks of exenatide treatment increases [(18)F]fluorodeoxyglucose uptake by brown adipose tissue without affecting oxidative resting energy expenditure in nondiabetic males
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J Exp Med (2016) 213(9):165562
It also reduces skin inflammation, eczema and improves skin elasticity
Adipose tissue serves as an endocrine organ that can aromatize androgens to estrogens
