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Importantly, the current clinical landscape reflects ongoing interest in this concept: while Roche has discontinued development of an NPY2R agonist, Gubra is advancing an NPY2R program in collaboration with Boehringer Ingelheim, suggesting that the hypothesis of pharmacologically optimized Y2 receptor engagement retains translational credibility

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Animal studies have suggested that GLP-1 receptors are expressed in various brain regions, including areas involved in stress response regulation