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People are losing weight, but suddenly saying, I dont think I look so healthy. The aging effects dont show up immediatelyat first, some patients may even appear healthier

41,42 GLP-1R is expressed in the cardiovascular system, and its knockout has implications for cardiovascular function

Guidance for industry: diabetes mellitus evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes

GLP-1 is secreted by the small intestine in response to nutrient ingestion

If HbA1c rises to 58 mmol/mol (7.5%) or higher, reinforce lifestyle advice and intensify medicines with a target of (7.0%) 53 mmol/mol

We know it can cause increase in gallstones and gallbladder disease