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The upregulation of mammalian target of rapamycin (mTOR), a master regulator of translation initiation, results in the increased expression of cancer-promoting genes such as eIF4E, a limiting factor for translation initiation in most cancers, including ovarian cancer [79,80]

A 2025 systematic review by Vasireddi and colleagues in HSS Journal screened 544 published papers and identified 36 meeting inclusion criteria 35 preclinical studies and only one human study: an uncontrolled, unblinded, retrospective case series of 12 patients receiving intra-articular BPC-157 for chronic knee pain, in which 7 of 12 (58%) reported self-described relief lasting more than 6 months, with no dose, effect size, or systematically collected adverse events published

doi: 10.1002/ajh.23182 [PubMed] 23953868 Cortazzo JA, Lichtman AD

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